Neuroprotection
The preservation of neuronal structure and function against damage, degeneration, or death caused by injury, disease, oxidative stress, or excitotoxicity.
Neuroprotection is a major research goal in neurodegenerative disease, traumatic brain injury, and stroke, as well as in cognitive performance optimization. Mechanisms of neuroprotection include reducing oxidative stress, dampening neuroinflammation, improving mitochondrial function, and supporting neurotrophic factor expression.
Several research peptides are studied for neuroprotective properties: Semax has preclinical data on BDNF upregulation and protection from ischemic damage; Cerebrolysin (a peptide mixture) has been investigated in clinical trials for stroke and Alzheimer’s disease; and Epithalon has been studied for its effects on oxidative markers in neuronal tissue. BBB penetration is a prerequisite for direct neuroprotective peptide action in the CNS.