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healing · recovery

KPV

Also known as: Lys-Pro-Val, Alpha-MSH C-terminal tripeptide
FDA: Not FDA-approved WADA: Not listed

KPV (Lys-Pro-Val) is the C-terminal tripeptide fragment of alpha-melanocyte-stimulating hormone (alpha-MSH). Despite being only 3 amino acids, it retains the full anti-inflammatory potency of the parent hormone while lacking its melanogenic (skin-darkening) effects. KPV's mechanism is unique among anti-inflammatory peptides: it enters the cell nucleus and directly inhibits NF-kB-driven inflammatory transcription, providing potent anti-inflammatory action through a melanocortin receptor-independent pathway. Its oral bioavailability makes it particularly attractive for gut inflammatory conditions (IBD, IBS, colitis), and recent research has demonstrated efficacy in acute lung injury models. KPV is one of the fastest-growing peptides in consumer interest, with +30% YoY search growth.

This content is for educational and research purposes only. VialBase does not provide medical advice. Consult a healthcare professional before using any peptide.

Molecular weight 342.43 Da
Half-life ~15-30 minutes estimated
CAS number —
Route Oral · Subcutaneous · Topical oral preferred
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Mechanism

C-terminal tripeptide of alpha-MSH — potent anti-inflammatory via NF-kB pathway inhibition; enters nucleus to directly suppress inflammatory transcription; melanocortin receptor-independent action

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Dosing

DOSE RANGE 200–500 mcg
FREQUENCY 1-2x daily
CYCLE LENGTH 4-8 weeks

Oral bioavailability makes it attractive for gut applications. Can be taken orally in capsule, SubQ injection, or topically. Oral dose typically 200-500 mcg 1-2x daily.

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Research summary

Study Type Year Key Finding
Host Defense Peptides with Immunoregulatory Mechanisms in IBD Review 2025 KPV grouped with host defense peptides (HDPs) for IBD treatment
SIPPC oral peptide delivery platform: KPV conjugate for colitis and acute lung injury Preclinical (mouse models) 2025 Self-Immolative Polymer-Peptide Conjugate (SIPPC) technology for oral peptide delivery
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Stacking & interactions

Gut healing powerstack — KPV anti-inflammatory + BPC-157 tissue repair

Anti-inflammatory + immune modulation

Anti-inflammatory + systemic tissue repair

Anti-inflammatory + anxiolytic for stress-driven inflammation

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Sourcing

Current prices

Updated today

4mg

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5mg

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10mg

500mg

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Size unspecified

Only vendor stocking this size on the VialBase roster.

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Also vetted at
What bloodwork do I need?

Reference ranges are general guidelines. Consult your physician for interpretation.

PRE-CYCLE
  • CMP
  • CBC
  • CRP
DURING CYCLE
  • CRP
POST-CYCLE
  • CMP
  • CBC
  • CRP
Safety & Regulatory Status
FDA STATUS Not FDA-approved
WADA STATUS Not listed

Regulatory status for KPV may change. Verify current status with your jurisdiction before use. This is not legal or medical advice.

References

  1. Various. Host Defense Peptides with Immunoregulatory Mechanisms in IBD. Various (2025). PMID: 41241376
  2. Various. SIPPC oral peptide delivery platform: KPV conjugate for colitis and acute lung injury. Science (or related high-impact journal) (2025). PMID: 41533788