Healing + skin

BPC-157 vs GHK-Cu

Comparing BPC-157 and GHK-Cu across evidence, dosing, mechanisms, and research areas.

vs
Category
healingrecovery
longevity
Molecular weight
1419.53 g/mol
340.38 g/mol
Half-life
~4 hours (stable in gastric juice — unique among peptides)
~1 hour (injectable); variable topical absorption
Admin routes
subcutaneousintramuscularoraltopical
topicalsubcutaneousintradermal
Research areas
Tendon/ligament repairGut healing (IBD, ulcers, leaky gut)Muscle injury recoveryNeuroprotectionBone fracture healingWound healingOrgan protection (liver, pancreas, heart)
Skin rejuvenation / anti-agingWound healingHair growth / follicle stimulationLung fibrosis / COPD repairAnti-inflammatoryBone regenerationNerve regeneration
Typical dosing
250–500 mcg · 1-2x daily · 4-12 weeks
200–500 mcg · 1x daily (injectable); 1-2x daily (topical) · 4-8 weeks (injectable); ongoing (topical)
FDA status
Not FDA-approved. Category 2 per FDA's 503A bulk drug substance framework (demonstrably difficult to compound). Previously Category 1 as of Feb 2026 reclassification — verify current status.
Not FDA-approved as drug. Available OTC in cosmetic formulations. Category 1 under 503A bulk drug substance framework (compoundable) for injectable use.
WADA status
Prohibited (S0 category — non-approved substances, effective January 2022)
Not prohibited (as of 2026)
PubMed studies
213
163